Soulful: A moth-like creature who controls her own "infection"; often thought to be related to the Radiance somehow. The Lifeblood "infection": A variant of Lifeblood, makes those infected stronger, isn't dangerous to others; also called Soulblood. It can be gotten by either consuming Soulblood directly, or it can randomly just happen. A transformation had a chance of occurring, where the "infected" creature(s) gain Lifeblood wings and possibly horns that are visible at nearly any given moment. The transformation isn't very comfortable at all, but once the pain's over, it's quite worth it, if you ask me.
Hollow Knight and Lifeblood belong to Team Cherry Soulful and Soulblood are originally mine First reference (ref) drawn with ibisPaintX